The event will start at 4pm (UK time) with a webcast from the Franklin Institute in Philadelphia, where they will be discussing the original telescopes used by Galileo to observe the heavens. In addition to other live webcasts from science centres around the world, there will be a 24-hour star party and a series of live webcasts from professional astronomers observing at 80 major telescope facilities around the globe.
If you would like to know more, then go to the official 100 hours of Astronomy website.